This plant substance can be helpful for stress, anxiety and depression

Resveratrol, which is found mainly in dark grapes, could be used as a natural antidepressant. The substance seems to reduce stress and even work against anxiety.

Autor: Dr. med. W. Tönnes 

Resveratrol: A plant substance against stress, anxiety and depression

Resveratrol is a secondary plant substance that belongs to the polyphenols and is found in particular in the skin and seeds of grapes. Cocoa and the red skin of peanuts also contain resveratrol, but only in small amounts.

Resveratrol is one of the antioxidants and has numerous health-promoting properties. It reduces the risk of glaucoma, has an anti-cancer effect and is also known as an anti-ageing substance.


Why does resveratrol work against stress, anxiety and depression?

This is where resveratrol comes into play. The secondary plant substance unfolds its anti-stress effect by blocking the enzyme PDE4, as shown in animal studies. As a result, resveratrol can also counteract depression and anxiety.

Dr. Ying Xu from the University of Buffalo pointed out that current antidepressants only affect serotonin or norepinephrine function in the brain, while the relationship between corticosterone and PDE4 remains unconsidered.

Perhaps this is the reason why only one third of depressed patients respond to current antidepressants, which are also associated with many side effects. Resveratrol could become an effective alternative for the treatment of patients with depression and anxiety disorders.

Unfortunately, since studies to date have been limited to animal studies, the required dosages for an antidepressant effect are not yet known.

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